EVALUATION OF ANTIDYSLIPIDEMIC AND ANTIOXIDANT POTENTIAL OF HIBISCUS SABDARIFFA, MORINGA OLEIFERA, ZINGIBER OFFICINALE, AND AZADIRACHTA INDICA HERBAL TEAS IN ALLOXAN- INDUCED DIABETES IN MALE WISTAR RATS
Numonde Emieseimokumo*, Ezekwe Ahmefula Sunday, Okari Karibo Amakiri, Momoh Isaac Sokoato*, Faith Owabhel Robert, Sheneni Victor Duniya
ABSTRACT
Several studies have suggested a significant negative correlation between antioxidant activities and lipid profile
parameters in diabetic patients. However, this study explores the therapeutic potential of herbal teas made from
Hibiscus sabdariffa, Moringa oleifera, Zingiber officinale, and Azadirachta indica. Diabetes was induced in seven
groups of six animals each through a one-time intra-peritoneal injection. These groups were then treated orally for
28 days with various combinations of alloxan and the herbal teas: alloxan + Zobo (100+400 mg/kg), alloxan +
moringa (100+200 mg/kg), alloxan + ginger (100+500 mg/kg), alloxan + ‘Dogoyaro’ (100+250 mg/kg), and
alloxan + glibenclamide (100+5 mg/kg). Dyslipidemia and oxidative stress markers were measured, revealing
significant reductions in total cholesterol (TC), LDL-C, and triglycerides (TG), and an increase in HDL-C in the
herbal tea-treated groups compared to alloxan alone. Hepatic antioxidant enzymes (GSH-px, SOD, and CAT)
decreased by alloxan were reversed by the herbal teas. Additionally, the teas reduced malondialdehyde (MDA)
levels in liver tissue elevated by alloxan.
Keywords: Antidyslipidemic, Antioxidant, diabetes, cardiovascular, alloxan.
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