European Journal of Biomedical and Pharmaceutical Sciences

PLASMACYTOMA OF THE SKULL MIMICKING A MENINGIOMA TWO CASE REPORTS AND REVIEW OF THE LITERATURE

*S. Bhallil, R. Ouidan, I. El Boutahiri, A. El Alaoui, S. Belkadi, R. Bentaher, I. Eddaif and S. Regragui

ABSTRACT

Cranial plasmacytoma is a rare tumor that can be isolated or part of a multiple myeloma context. The
differential diagnosis between plasmacytoma and meningioma is often challenging, as both can present
radiological similarities. In this article, we present two cases of cranial plasmacytoma in women with a
cranial mass initially diagnosed as meningioma based on imaging. In the first case, the plasmacytoma was
isolated, without progression to multiple myeloma, while the second case revealed multiple myeloma. Both
patients underwent surgical excision. This work emphasizes the importance of performing a preoperative
assessment, including a biopsy, especially in cases of suspected meningioma, to avoid missing a cranial
plasmacytoma or even multiple myeloma.

Keywords: skull plasmacytoma, meningioma, multiple myeloma, biopsy, preoperative assessment.