FORMULATION AND EVALUATION OF CARVEDILOL NASAL MICROSPHERES
Swapnil B. Jaiswal, *U. T. Jadhao, Sayyed Asad Ali, G. N. Dhembre, S. A. Wathore and S. T. Thoke
ABSTRACT
The aim of this research work was the formulation and evaluation of nasal microsphere of loaded with carvedilol.
Microsphere was prepared by simple w/o emulsification-cross linking process. The microspheres were formulated
using Chitosan in different drug to polymer ratio ie. 1:1,1:1.5, 1:2, 1:2.5 and 1:3, by keeping stabilizer, cross
linking, and stirring speed constant. Total five batches were prepared and batches were subjected to
characterization study like % yield, particle size analysis, drug entrapment efficiency, drug content and %
mucoadhesion. It was found that average percentage yield was greater than 50 % for all the batches. It was found
that % yield increases with increase in polymer weight concentration. Drug entrapment efficiency and %
muchoadhesion was found to be optimum for all batches. It was noted after study that as the concentration of
polymer increases, drug entrapment and percentage muchoadhesion also increases. The in vitro drug release
profile of all the formulation of Carvedilol was showed sustained release of drug for extended period of time. The
developed formulation (F5) was found to be stable during the stability study period of 3 month indicating good
stability of the microsphere.
Keywords: Carvedilol, Mucoadhesion, Chitosan, Nasal Microsphere.
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