THE IMPACT OF METFORMIN ON THE BONE MINERAL DENSITY AND QUALITY OF LIFE IN NON DIABETIC POSTMENOPAUSAL WOMEN WITH OSTEOPOROSIS
Dr. Suneel Kumar*, Rajanikant Srivastava, Partap Singh Ghalaut, Narender kumar Maggu, Rajesh Kumar Rohilla and Vandana Shan
ABSTRACT
To determine the effects of metformin on bone mineral density changes and quality of life in non-diabetic post menopausal women with osteoporosis. Fourty patients of age 40-65 years meeting inclusion criteria were equally divided into 2 groups. Patients of group-A received medications of osteoporosis for a period of 12 months while patients of group – B received tablet metformin 500 mg as add on to medications of osteoporosis a period of 12 months. Bone mineral density, biochemical parameters and quality of life were assessed at 0, 3, 6 and 12 months of the study. Addition of metformin to medications of osteoporosis could not produced significant changes in bone mineral density and was found to be comparable in patients not received metformin after completion of 12 months of the study.It was found that the quality of life had improved significantly in metformin group (p<0.001). Metformin was well tolerated without any significant adverse effects and bone fractures. However, further studies with larger number of patients and of longer duration are required to reach concrete conclusion regarding impact of metformin on bone mineral density in postmenopausal women with osteoporosis.
Keywords: Osteoporosis, post menopause, metformin, quality of life.
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