A REVIEW ON UV, HPLC AND HPTLC ASSESSMENT TECHNIQUES AVAILABLE ON PAIN RELEIVING AND ANTI INFLAMMATRY DRUGS
Dipanshu Gehlod*, Professor Krishna Kalsara, Dr. Chainesh Shah and Dr. Umesh Upadhyay
ABSTRACT
The evaluation of pain-relieving and anti-inflammatory drugs, including NSAIDs and opioids, is crucial for
ensuring therapeutic efficacy and safety. Analytical techniques such as UV spectrophotometry, High-Performance
Liquid Chromatography (HPLC), and High-Performance Thin Layer Chromatography (HPTLC) are widely
utilized for this purpose. UV spectrophotometry offers a rapid and cost-effective means of quantifying drug
compounds based on UV light absorption, though it lacks specificity compared to chromatographic methods.
HPLC provides high sensitivity and resolution, enabling precise separation, identification, and quantification of
drug components in complex matrices, making it a gold standard for drug analysis. HPTLC is a versatile and
efficient method that allows simultaneous analysis of multiple samples with minimal solvent use, but it generally
has lower sensitivity compared to HPLC. This review outlines the principles, advantages, and limitations of these
techniques, highlighting their roles in drug quality control and regulatory compliance.
Keywords: Pain-relieving drugs, Anti-inflammatory drugs, NSAIDs, Opioids, UV spectrophotometry, High- Performance Liquid Chromatography (HPLC), High-Performance Thin Layer Chromatography (HPTLC), Drug analysis, Analytical techniques, Drug quality control, Therapeut
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