ANTI INFLAMMATORY EFFECT OF SIDDHA HERBAL DRUG AZHAVANAM VERPATTAI CHOORNAM USING IN SILICO MODEL. A COMPUTATIONAL STUDY TO PREDICT ITS EFFICACY IN TREATING MENORRHAGIA
Neethu P.*, P. Hemavathi, Vignesh K., Rafic Raja K. P. S. and Sundararajan S.
ABSTRACT
Background: Siddha medicine is a form of traditional medicine originating in southern India. It is one of the
oldest systems of medicine in India. Siddhars have classified disease into 4448 types. In this modern mechanical
world, now-a-days people are suffering from various disease. Especially females are the majority of sufferers due
to their dual role both in family as well as society. One among the diseases in menstrual disorders is the
“Perumbadu’’. Sage Yugi classified ‘Perumbadu’ in his Yugi Vaidhya Chinthamani into 4 types. Of these Vatha
Perumbadu is one of them. Perumbadu in Siddha can be compared with Menorrhagia. The present study focus on
Azhavanam ver pattai choornam, a herbal formulation recommended for Menorrhagia treatment as mentioned in
Gunpadam-Mooligai. The Primary objective of this research is to investigate the in-vitro anti Inflammatory
activity and biochemical properties of Azhavanamverpattai choornam. Aim: The aim of the study is to analyze the
in-vitro Anti Inflammatory activity of Azhavanam verpattai choornam. Methodology: This study investigates
theAnti inflammatory potential of Azhavanam verpattai choornam by examining how its phytocomponents bind to
specific aminoacids (His70, Asp71, Ser72, Val91, Pro117,Ser119,Thr120,Pro121,Ser122,Thr124,Thr125) of the
target by forming hydrogen bond will hinder the function of the inflammatory cytokine IL6(Interleukin6) with
PDB-1N26. These amino acid residues are functionally responsible for binding of substrate and inhibitors. There
by Phytocomponents which inhibit the target IL6(Interleukin 6) may act as a potential therapeutic agent for
management of inflammation. Result: The study result of Azhavanam verpattai choornam has significant Antiinflammatory
activity.
Keywords: Perumbadu, Menoirrhagia, Azhavanam verpattai choornam, Anti-inflammatory activity.
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