ANTI-ULCER EFFECT OF SIDDHA POLYHERBAL FORMULATION MAHALAVANGATHI CHOORNAM BY USING IN-SILICO MODEL
Rafic Raja K. P. S.*, Navasiddhan A. T., Pavithra S., Vignesh K. and Balamurugan A.
ABSTRACT
Background: The Siddha system of medicine, traditionally practiced in South India, particularly in Tamil Nadu,
recognizes Gunmam (equivalent to Peptic Ulcer) as one of the 4448 documented diseases. This condition is
described by Siddhar Yugi Muni in "Yugi Vaithiya Chinthamani". The present study focuses on Mahalavangathi
choornam, a polyherbal formulation recommended for Gunmam treatment, as mentioned in "Anuboga Vaidhya
Brahma Ragasiyam Moondram Paagam". The primary objective of this research is to investigate the in-vitro antiulcer
activity of Mahalavangathi choornam. Aim: This study aims to investigate the in-vitro anti-ulcer activity of
Mahalavangathi choornam. Methodology: This study investigates the anti-ulcer potential of Mahalavangathi
choornam by examining how its phyto components bind to specific amino acids (LYS-445, VAL-473, and TYR-
475) on the H. pylori urease enzyme (PDB: 1E9Y), forming hydrogen bonds that disrupt enzyme activity. By
inhibiting urease, which converts urea to ammonia and contributes to ulcer development, these phyto components
may offer a therapeutic approach for managing H. pylori-associated ulcers. Result: Mahalavangathi choornam has
significant Anti-ulcer activity.
Keywords: Gunmam, Peptic Ulcer, H pylori Urease, Siddha.
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