MOLECULAR DOCKING STUDIES OF SIDDHA HERBAL FORMULATION KALLADAIPPU KUDINEER ON TAMM – HORSEFALL PROTEIN INVOLVED IN CALCIUM OXALATE CRYSTALLIZATION OF UROLITHIASIS
Pavithra S.*, Aishwarya S., Rafic Raja K. P. S., Vignesh K., Gomathi P. and Balamurugan A.
ABSTRACT
Siddha medicine is one of the most ancient medical systems of India and is the mother medicine of ancient Tamils
/ Dravidians of peninsular south India. Fundamental principles of siddha include theories of five elements
(Aimpootham) and three humors (mukkutram). According to classical siddha system of medicine, the clinical
features of Kalladaippu noi is widely correlated with the disease called Urolithiasis(Renal stone), which is a
common disorder found in humans of all ages due to changing lifestyle and dietary choices that leading to
increased incidence and prevalence around the globe. In siddha medicinal literatures, there are many herbs which
are used to prevent the recurrence of stone formation through anti-inflammatory, lithotriptic, anti-spasmodic
action. This article reviews about the anti urolithiatic activity of herbal formulation Kalladaippu kudineer
intraction with Tamm – Horsefall -Protein involve in ca. oxalate crystallization.
Keywords: Urolithiasis, Anti urolithiatic activity, Tamm- Horsefall Protien.
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