ULTRASTRUCTURAL CHANGES OF PAROTID AND SUBMANDIBULAR GLANDS OF RATS IN STREPTOZOTOCIN-INDUCED DIABETES MELLITUS
*Iryna M. Yavorska-Skrabut, Ilya Ye. Herasymyuk, Kostantin S. Volkov, Anton V. Hantimurov
ABSTRACT
Diabetes mellitus (DM) leads to a significant deterioration in the quality of life as a result of chronic complications associated primarily with angiopathy. In the article the ultrastructural changes in the secretory epithelium and state of microcirculatory bed of parotid and submandibular glands of white rats with experimental streptozotocin-induced diabetes duration 1, 2 and 3 months have been studied. Ultramicroscopic study of submandibular gland with diabetes showed the presence of significant destructive changes in the endothelium of the capillaries in the early stages of observation, which became more prominent with longer duration of hyperglycemia. Changes of microcirculation caused impairment transport of oxygen and nutrients to glandulocytes, leading to disruption of synthesis and excretion of secrets. Destructive changes of mucocytes and serocytes submicroscopic organization indicate violations of the functional activity of acinar cells. Electron microscopic research of parotid gland in experimental diabetes mellitus also found a violation of microcirculation that significantly worsened secretion. Reorganization of secretory epitheliocytes were accompanied by damage of nuclei and cytoplasmic organelles that gradually decreased synthetic processes in serocytes and excretion of secret.
Keywords: Diabetes mellitus, salivary glands, blood vessels.
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