European Journal of Biomedical and Pharmaceutical Sciences

DEVELOPMENT AND EVALUATION OF EXTENDED-RELEASE TABLETS OF LOSARTAN POTASSIUM & ENALAPRIL MALEATE”

Vijay Kisan Jambhale*, Reena Shinde and Satkar Prasad

ABSTRACT

The oral route of drug delivery is considered as the preferred and most patient convenience means of drug administration. Consequently, much effort is directed during drug discovery to identify orally active candidates that will provide reproducible and effective plasma concentration in vivo. The reality is that many compounds are either incompatibility or ineffectively absorbed after oral administration (bioavailability is an issue), or that the required during frequency is too short to enable once or twice daily administration (pharmacokinetic half-life in an issue). Conventional drug delivery systems have little or no control over drug release. This may result from constantly changing, unpredictable plasma concentrations. The rate and extent of drug absorption from conventional drugs may vary greatly depending on factors such as the pysico-chemical properties of drugs, presence of excipients the presence or absence of food, pH of the gastro-intestinal tract, and so on.

Keywords: oral route, half-life, Conventional drug delivery systems, administration.