FROM FORMULATION TO FUNCTION: A REVIEW OF TRANSFEROSOMES AND THEIR PREPARATION METHODS
Sijamol C. S.*, Hasnamol and S. Mahendran
ABSTRACT
Transferosomes is a carrying body for targeted transdermal drug delivery system. This are special types of liposomes, consisting of phosphatidylcholine and an edge activator. This system also takes advantage of phospholipids vesicles as transdermal drug carrier. It penetrate the stratum corneum by either intracellular route or the transcellular route by the generation of “osmotic gradient”. Advantages of Transferosomes are wide range of solubilities, better penetration, biocompatible and biodegradable etc. This comprehensive review delves into the realm of transferosomes, lipid-based nanocarriers that hold immense potential in drug delivery. Beginning with an overview of their formulation, this paper explores the various methods employed in the preparation of transferosomes, ranging from thin film hydration to reverse-phase evaporation. A detailed analysis of their structural characteristics, including size, morphology, and membrane composition, is provided, shedding light on their remarkable ability to encapsulate both hydrophilic and hydrophobic drugs. Furthermore, the mechanisms underlying their enhanced transdermal and transmucosal delivery are elucidated, along with their applications in addressing various therapeutic challenges. Recent advancements in transferosome technology are discussed, along with future prospects in the field.
Keywords: Transferosomes, Nanocarriers, Transdermal drug delivery, Transmucosal delivery.
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