LONG TERM ADMINISTRATION OF HERBAL ALCOHOL BITTERS (1960 ROOTZ) ALONE AND IN COMBINATION WITH KOLAVIRON MAY INCREASE INTESTINAL MOTILITY AND TRANSIT IN ALBINO WISTAR RATS
Okon Victoria Edem*, Idam Benedict Umagu and Abong Edward
ABSTRACT
This study was aimed at investigating the effects of long term administration of herbal alcohol (1960 rootz) bitters
alone and in combination with kolaviron on intestinal motility and transit in albino wistar rat model. Fifteen (15)
female rats weighing 100-190g were used. The rats were randomly divided into three groups containing five (5)
rats each. Group 1 was control group and was fed with normal rat chow and 0.2ml normal saline. Group 2, herbal
alcohol only, received 0.3ml/100g body weight and fed normal rat chow and water. Group 3, herbal alcohol +
kolaviron received 100mg/kg body weight of kolaviron and 0.3ml/100g rat body weight of herbal alcohol
alongside with normal rat chow and water. The results obtained following 21 days administration of the drugs and
experiment, showed that at low doses of ACh concerntration, (10-9M), there was a significant (P<0.05) increase in
maximum contraction of the ileal smooth muscle in the test groups (herbal alcohol only and herbal alcohol +
kolaviron) as compared to control. At moderate doses of ACh concerntration (10-7M), the result showed a
significant (P<0.05) increase in the herbal alcohol group compared to control and herbal alcohol + kolaviron test
group. Also, the result showed that at high doses of ACh concerntration (10-5M), the test groups had a significant
(P<0.05) increase in maximum contraction as compared to control. The test groups showed an increase in
intestinal motility but no effect on transit. However, a combination of both drugs further increased intestinal
motility. Therefore, both drugs (herbal alcohol + kolaviron) may be beneficial to people suffering from
constipation. However, it should be taken with caution.
Keywords: Herbal alcohol bitters, 1960 rootz, kolaviron, Garcina cola, intestinal motility, transit.
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