European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF PHYSICO-CHEMICAL CHARACTERIZATION OF NANOEMULSION CONTAINING ANTI-ALZHEIMER DRUG (MEMANTINE HYDROCHLORIDE)

S. Md. Zubair*, A. V. Deepthi, L. Suprabha, N. Likhitha, S. K. Sree Harsha and U. Kartheek

ABSTRACT

Aim: This study aimed to develop and evaluate a nanoemulsion-based delivery system for Memantine Hydrochloride, an anti-Alzheimer's drug, to improve its solubility, stability, and ability to cross the blood-brain barrier (BBB), thereby enhancing its therapeutic efficacy. Methods: The nanoemulsion was formulated using an oil-in-water emulsion technique, and its physicochemical properties were assessed using UV spectroscopy, Fourier-transform infrared (FTIR) spectroscopy, particle size analysis, and zeta potential measurements. In vitro, drug release studies were conducted to evaluate the release profile of Memantine Hydrochloride from the nanoemulsion. Results: The nanoemulsion showed a significant improvement in the solubility and stability of Memantine Hydrochloride, as confirmed by UV and FTIR analysis. The particle size was within the nanometer range (50– 200 nm) with a stable zeta potential. In vitro drug release studies demonstrated a sustained release profile over 24 hours, indicating controlled and prolonged drug availability. Conclusion: The nanoemulsion-based delivery system effectively enhanced the solubility, stability, and brain-targeting potential of Memantine Hydrochloride, making it a promising approach for improving Alzheimer's treatment. This formulation could lead to more efficient and sustained drug delivery, reducing dosing frequency and improving patient outcomes.

Keywords: Alzheimer's disease, nanoemulsion, Memantine Hydrochloride, blood-brain barrier, drug delivery, UV spectroscopy, FTIR analysis, controlled release, neurodegenerative disorders.