CORRELATION MARSH CLASSIFICATION AND TISSUE TRANSGLUTAMINASE TITER WITHIN PEDIATRIC JORDANIAN CELIAC PATIENTS
Mohammad Rwalah MD., Mohammad Shatanawi MD., *Hosam Alshurafa MD., Baraa Alfalahat MD., Mohammad AlShakhatreh MD, Mohammad Quraan MD., Lara Mikhi MD. and Habeeb Etewi MD.
ABSTRACT
Objective: Celiac disease is an immune mediated systemic disorder elicited by ingestion of gluten in genetically susceptible individuals, characterized by variable clinical manifestations, specific antibodies, enteropathy with variable histology staging. The aim of this study to investigate the correlation between tissue transglutaminase (TTG) titter and histology staging according to MARSH classification. Methods: Data were collected retrospectively from electronic medical files and the endoscopy archive at Queen Rania Children‘s Hospital. The study period, from January 2016 to December 2023 January, included a group of 146 Jordanian paediatric patients aged between 4 and 14 years of both genders and confirmed the diagnosis of celiac disease by histopathology and positive TTG serology test, the selected patients varied in their TTG titer level, we checked the correlation between MARSH histology stages and TTG levels. Results: The high titter TTG (>100unit) observed with 74 patients (50,7%), 62 patients (83,8%) of them found associated with advance histology grade according to MARSH classification, while 72 patients (49.3%) with low TTG tit(<100**) 54 (75%) of them had advance histology grade. Conclusion: advance MARSH histology grading among Jordanian paediatric celiac patients is observed with majority number of both High and low TTG titter.
Keywords: Celiac, Tissue Transglutaminase, Marsh Clasification.
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