European Journal of Biomedical and Pharmaceutical Sciences

A REVIEW OF MUCOSAL DRUG DELIVERY- INNOVATION AND APPLICATION

Parmeshwar Karbhari Budhwat, Sakshi Omprakash Jaju*, Dr. Swati S. Rawat, Dr. Sunil S. Jaybhaye and Datta Babasaheb Chaudhari

ABSTRACT

Mucosal drug delivery systems have emerged as a pivotal approach in pharmacotherapy, offering advantages such as bypassing first-pass metabolism and enhancing bioavailability. Recent innovations in this field include the development of Nano-formulations, biodegradable polymers, and targeted delivery mechanisms, which improve drug absorption through mucosal surfaces such as the oral, nasal, and rectal mucosa. These advancements not only facilitate the administration of a wide range of therapeutics, including peptides, vaccines, and small molecules, but also enhance patient compliance by providing non-invasive delivery options. This review explores the latest breakthroughs in mucosal drug delivery technologies, their mechanisms of action, and their clinical applications, highlighting their potential to revolutionize treatment paradigms in various therapeutic areas, including respiratory diseases, gastrointestinal disorders, and systemic vaccinations.

Keywords: Anatomy of oral cavity, Mucoadhesion, Theories of mucoadhesion, Factors, Evaluation test.