Abstract
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF PRAVASTATIN AND BEMPEDOIC ACID IN BULK AND PHARMACEUTICAL FORMULATION

Gorantla Nagamallika* and Jadav Ajay

ABSTRACT

A simple, rapid, accurate and precise reverse phase high performance liquid chromatographic technique has been progressed for the determination of Pravastatin and Bempedoic acid in absolute form and tablet. Separation of drug peaks were achieved on a Gemini C18 1μ10 Å, LC Ea 150mm x 4.6mm; 5μm column using a mixture of 0.025mM KH2PO4 PH 2.5 and Acetonitrile (60:40) as the mobile phase at rate of flow 1.0ml/min, the recognition was accomplished at 272nm. The retention time of the Pravastatin and Bempedoic caid was 2.398 and 4.801min correspondingly. The approach generates linear reaction in the concentration series of 6-30μg/ml of Pravastatin and 36-270μg/ml of Bempedoic acid. The precision for the assay was below 2.0%RSD. The %recovery for the accuracy was in between 99-101%. The method will be useful in the quality check assessment of Pravastatin and Bempedoic acid in bulk and pharmaceutical formulations.

Keywords: Pravastatin, Bempedoic acid, RP-HPLC, Validation, Pravastatin and bempedoic acid tablets.


[Full Text Article]   [Download Certificate]

Indexing

Indexing

Best Article Awards

European Journal of Biomedical and Pharmaceutical Sciences (EJBPS) is giving Best Article Award in every Issue for Best Article and Issue Certificate of Appreciation to the Authors to promote research activity of scholar.

Best Article of current issue :

Dr. Dhrubo Jyoti Sen

Download Article : Click here

News & Updation

  • EJBPS: New Impact Factor 2026

    EJBPS Impact Factor has been Increased from  7.482 to 8.181 for Year 2026.

  • EJBPS: FEBRUARY ISSUE PUBLISHED

    FEBRUARY 2026 Issue has been successfully launched on 1 FEBRUARY 2026.

  • Index Copernicus Value

    EJBPS Received Index Copernicus Value 77.3, due to High Quality Publication in EJBPS at International Level

  • Journal web site support Internet Explorer, Google Chrome, Mozilla Firefox, Opera, Saffari for easy download of article without any trouble.

    .

  • Article Invited for Publication

    Dear Researcher, Article Invited for Publication  in EJBPS coming Issue.

     
Google Scholar Index Copernicus Indian Science Publications Urlich's Periodicals Directory, Proquest, UK (In Process) Research Bible, Fuchu, Tokyo. JAPAN UDLedge Science Citation Index International Society for Research activity (ISRA) Scientific Indexing Services (SIS) InfoBase Index (In Process) SJIF Impact Factor Scholar Article Impact Factor, SAIF Universal Impact Factor CAS (A Division of American Chemical Society) USA (Under Process) Directory of Open Access Journal (DOAJ, Sweden, in process) CiteFactor Directory Of Research Journal Indexing (DRJI) Indian citation Index (ICI) Journal Index (JI, Under Process) Directory of abstract indexing for Journals (DAIJ) Open Access Journals (Under Process) Impact Factor Services For International Journals (IFSIJ) Cosmos Impact Factor Jour Informatics (Under Process) Eurasian Scientific Journal Index (ESJI) International Innovative Journal Impact Factor (IIJIF) Science Library Index, Dubai, United Arab Emirates Global Impact Factor (GIF) (0.377) IP Indexing (IP Value 3.77) Web of Science Group (Under Process) Directory of Research Journals Indexing Scope Database Academia Academia Doi-Digital Online Identifier Doi-Digital Online Identifier ISSN National Centre Zenodo Indexing International CODEN Service, USA

UG/PG/Ph.D Research Publication

Research Scholar of UG/PG/Ph.D can Submit their Research Article/Review Article/Case Study/Short Communication for Publication in EJBPS

Downloads

Copyright From

Covering Letter

                        Author Instruction 
 

PLAGERLUM REPORT