ANTI-MALARIAL ACTIVITY OF GIGANTEONE-A ISOLATED FROM FRUIT RIND OF MYRISTICA MALABARICA LAM
Ajoy K. Bauri*, Joshua H. Butler, Grant J. Butschek, Maria B. Cassera and Sabine Foro
ABSTRACT
M. malabarica is an evergreen belonging to family Myristaceae and an Indian medicinal plant used as botanical medicine to cure different types of diseases reported in traditional medicinal system, ′Ayurveda‵ from very antiquity. The dry fruit rinds are also used as an active ingredient for preparation of exotic spices known as ‘garam masale’ used in various Indian cuisine. Chemical profiling of defatted fruit rind of methanol and 20% aqueous methanol extract revealed that the presence of a diaryl nononoids a class of compounds generically known as malabaricones as major constituents along with the dimers of acyl phenol known as giganteone (dimeric form of malabaricone C). Structural characterization of these compound has been carried out by chemical, spectral and spectrometric methods by comparison with published spectroscopic data available in literature and in some cases confirmed by single crystal X ray diffraction study of crystallizable compounds where it as applicable. In vitro anti-malarial assay of these compounds, 1-10 has been carried out against Plasmodium falciparum. Experiment results revealed that a dimer of acyl phenol known as giganteone A (dimeric malabaricone C) had moderate anti-malarial activity.
Keywords: M. malabarica; fruit rinds; phenols, acyl dimer giganteone A; isolation & characterization; anti-malarial activity.
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