European Journal of Biomedical and Pharmaceutical Sciences

COLON TARGETED DRUG DELIVERY: AN EXTENSIVE OVERVIEW

Supriya Shirke*, Kishor Burade, Prajakta Kakade, Shivkumar Sontakke and Rajshri Tambe

ABSTRACT

In addition to providing access to specific therapeutic targets, colon drug administration may improve drug absorption while lowering off-target effects. Formulation development is necessary for drug delivery to the colon since the unique physiological surroundings of the colon might provide difficulties for both oral and rectal dose forms. The international pharmaceutical market for biologics has expanded recently, and the growing need for a better drug delivery system emphasizes the significance of colonic drug delivery as a non-invasive method of delivering macromolecules. Better patient compliance and reduced expenses are two therapeutic advantages that this method may offer. Consequently, a number of strategies, including pH-dependent, enzyme-triggered, receptor-mediated, and magnetically driven systems, have been investigated in order to accomplish efficient local and systemic colon drug delivery. Recent developments in a variety of methods for creating colon-targeted drug delivery systems and their pharmaceutical uses are discussed in this study. The best in-vitro, in-vivo, and in-silico preclinical research are then conducted.’

Keywords: Drug delivery system, Bioavailability, Biologics, Colon targeting, preclinical investigation.