HYDRAZONES AS PROSPECTIVE ANTI-HIV AGENT
Shweta Singh, Bechan Sharma* and Nikhat J. Siddiqi
ABSTRACT
Hydrazones are a special class of organic compounds prevalent in both chemical and biological contexts. These
heterocycles bearing nitrogen and carbon moieties constitute the core structure of a number of biologically
interesting compounds for biological activities like antiHIV-1RT, anti-DNA polymerase and anti-RNase H
activities. Hydrazones thus act as a dual novel small molecule against HIV-1. Hydrazones are shown to interact
with viral capsid protein and inhibit its final processing. It constitutes >C=N-NH2 group which is reported to be
highly efficient for development of an antiviral agent. A thorough search for different actions of hydrazone
indicates that only scanty information is available on their interactions with activities of viral integrase and
protease. The existing information suggests that more efforts are needed now to develop more efficient hydrazones
and their derivatives against several viable targets in HIV-1 life cycle to block viral proliferation without toxicity
to the hosts. This review highlights the properties and activities of hydrazones and their various chemical
derivatives as antiHIV-1 compound.
Keywords: biological activity, hydrazones, heterocycles, capsid protein, HAART.
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