SEROPREVALENCE OF DENGUE FEVER AMONG FEBRILE PATIENTS IN KASSALA STATE, EASTERN SUDAN
Alzubair M. Ahmed, Abdualmoniem O. Musa, Hasan A. Ibrahim, Yasir B. Ahmed, Nadir M. Abuzeid*
ABSTRACT
Background: Dengue virus is a significant health threat in Sudan, with recurrent outbreaks affecting tropical and subtropical regions. Objective: The study aimed to investigate the epidemiological and serological test of DENV infection in Kassala state. Methodology: A cross-sectional study was conducted in 2023 among 273 febrile patients at Kassala state, Eastern Sudan. Result: Out of 273 blood samples, 100 (36.63%) tested positive for NS1 Ag. Male participants (70%) and urban residents (92%) exhibited significantly higher infection rates, with statistical associations with P. value ˂ 0.05. Regarding clinical manifestations, certain symptoms were a high prevalent among DENV NS1 Ag-positive patients. Back pain 88(88%), Join pain 87(87%), skin rash 12(12%), sweating 79(79%), chills 71(71%), bleeding 11(11%), and polyarthralgia 69(69%). Moreover, significant correlations were found in headache, back pain, joint pain, skin rash, sweating, chills, bleeding, and polyarthralgia with (X2=43.374, P value = 0,001215), (X2= 18.23, P value = 0.001), (X2=18.749, P value = 0.0013), (X2= 13.404, P value = 0.00230), (X2=14.583, P value = 0.0025), (X2=56.133, P value = 0.001), (X2=19.829, P value = 0.000011), (X2=26,941, P value =0, 0021753), respectively. Conclusion: Dengue virus poses a significant health challenge in Kassala state, with 36.63% NS1 Ag positivity, predominantly among male and urban residents. Key clinical manifestations such as back pain, joint pain, and chills showed significant correlations with infection. Enhanced diagnostic efforts and targeted interventions are essential to combat dengue in this region.
Keywords: engue, Seroprevalence, Kassala, Sudan, Fever.
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