European Journal of Biomedical and Pharmaceutical Sciences

REGIO-SELECTIVE BROMINATION REACTION OF HYDROXY ACETOPHENONES USING NBS AS BROMINATING REAGENT

Ajoy Kumar Bauri*

ABSTRACT

Freshly crystallized NBS has been used to brominate hydroxy acetophenone at low temperature in aqueous acetone as solvents. From experimental results it has been observed that NBS is excellent region-specific brominating reagent for ortho hydroxy acetophenones provided ortho position of hydroxy acetophenones must be unsubstituted. The bromination took place at adjourning position of hydroxy group of the hydroxy acetophenones and would provide quantitative yield when 1.2 equivalent NBS used as reagent. The temperature of reaction mixture has been maintained at 0 ⁰C and reaction mixture has been stirred over a period of 12-48 h with the help of a stirrer. Twenty-five different kinds of hydroxy acetophenones have been used to study the reactions and to optimize the reaction condition.

Keywords: Hydroxy acetophenone; bromination; N-bromo succinimide; low temperature; aqueous acetone as solvent; regio-specific bromination.