European Journal of Biomedical and Pharmaceutical Sciences

EFFECTS OF ETHANOLIC EXTRACTS OF AZADIRACHTA INDICA, CYMBOPOGON CITRATUS AND OCIMUM GRATISSIMUM ON THE HAEMATOLOGICAL INDICES, FOLLOWING PLASMODIUM BERGHEI-INDUCED MALARIA IN MICE

Ezeokafor Emmanuel Nonso, Nwankwo Azubike A., David Chibuike Ikwuka, Ifemenam Kosisochukwu Emmanuel*, Ifebi Kenechukwu Onyeka, Dike Charles Chijioke, Onoriode Akpghene Eyeghre, Uzoh Casmir Ifunanya and Ottih Chidalu Jennifer

ABSTRACT

The world is faced with many diseases of public health importance. Malaria for Centuries has pluged the world especially the sub- Saharan Africa. This study explores the antimalarial effects of cymbopogon citratus (lemongrass), ocimum gratissimum, and azadirachta indica on the hematological indices in wista rats. Fifty male mice were purchased from a local market, animals were maintained with normal laboratory chow (Grower feed) and water ad libitium. The animals were acclimatized for two weeks before induction of the Plasmodium berghei and ethanolic leave extract of Azadirachta indica, Cymbopogon citratus and Ocimum gratissimum. Plasmodium berghei were inoculated intraperitoneally with 0.2ml blood suspension. Group A was the Negative control group, induced with plasmodium berghei without any treatment. Group B was Positive control, received only food and water. Group C was induced with P. berghei and treated with (500 mg/kg) of Azadirachta indica. Group D was induced with P.berghei and treated with (100 mg/kg) ethanolic extract of Cymbopogon citratus. Group E was induced with P.berghei and treated with (500mg/kg) ethanolic extract of Cymbopogon citratus. Group F was induced with P.berghei and treated with 100mg/kg) ethanolic extract of Ocimum gratissimum. Group G was induced with P. berghei and treated with (500mng/kg) ethanolic extract of Ocimum gratissimum. Group H was induced with P.berghei and treated with (100mg/kg) ethanolic extract of Azadirachta indica. Group I was induced with P.berghei and treated with standard drug. Group J was induced with P. berghei and treated with (500mg/kg) ethanolic extracts of the leaves (Azadirachta indica, Cymbopogon citratus, and Ocimum gratissimum). The Administration of the extract lasted for 7 days.

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