European Journal of Biomedical and Pharmaceutical Sciences

PHARMACOLOGICAL EVALUATION AND NEPHROPROTECTIVE POTENTIAL OF THUNBERGIA ERECTA FLOWER EXTRACT IN A RAT MODEL

*Ashok Ahirwar, Rahim Khan, Dr. Ravi Prakash and Priyanka Dangi

ABSTRACT

This study evaluates the nephroprotective activity of the methanolic extract of Thunbergia erecta in Gentamycin-induced nephrotoxicity in rats. Phytochemical analysis revealed the presence of alkaloids, flavonoids, glycosides, tannins, and phenols. Gentamycin administration led to marked renal damage, characterized by apoptosis, necrosis, and increased serum creatinine levels, mimicking acute renal failure. Treatment with Thunbergia erecta extract (100 mg/kg and 200 mg/kg) significantly improved renal function, as evidenced by restored body weight, increased urine output, and reduced serum creatinine. Histopathological examination confirmed that the extract reversed kidney damage and restored normal kidney architecture. These findings suggest that Thunbergia erecta possesses potent nephroprotective activity, likely due to its antioxidant properties and flavonoid content, making it a promising candidate for future research in nephrotoxicity management.

Keywords: Thunbergia erecta, nephroprotective activity, Gentamycin-induced nephrotoxicity, serum creatinine, histopathology.