European Journal of Biomedical and Pharmaceutical Sciences

HISTOMORPHOLOGIC CORRELATION OF PSA LEVELS IN BENIGN, PREMALIGNANT & MALIGNANT LESIONS OF PROSTATE

Reshma A. Nadaf, Ashwini N., Shayan N. Pavaskar and Apurva G. Yadav*

ABSTRACT

Background: Due to the widespread use of serum PSA (Prostate specific antigen)as a mass screening test for prostate cancer there has been an ever increasing number of prostate needle biopsies and hence the need to give an accurate diagnosis despite the limitations. Present study was aimed to study histomorphologic correlation of PSA levels in benign, premalignant & malignant lesions of prostate. Material and Methods: Present study was single-center, cross sectional study, conducted in prostate biopsies/transurethral resection of prostate (TURP) specimens/prostatectomies received. The PSA level in serum is estimated and correlated with histopathological diagnosis. Results: In present study, 31 cases of various prostatic lesions were studied. Common lesions were prostatic adenocarcinoma (32.5 %) & benign prostatic hyperplasia (32.5 %) followed by high grade prostatic intraepithelial neoplasia (22.5 %), atypical small acinar proliferation (7.5 %) & atypical adenomatous hyperplasia (5 %). As per histopathology reports, majority lesions were premalignant (35 %), followed by benign & malignant lesions (32.5 % each). Raised age specific PSA levels were noted in 27 cases (67. 5%). PSA is not a specific marker for Prostatic malignancy, as four cases out thirteen cases of BPH showed abnormal PSA levels. PSA level was raised in all the prostatic adenocarcinoma cases. Ten cases out of fourteen premalignant cases showed raised PSA There was statistically significance is established between age specific PSA levels and Histopathology reports. There was significant difference in PSA levels between Benign and malignant lesions (p value<0.05). There was significant difference in PSA levels between malignant and premalignant lesions (p value<0.05). There was no significant difference in PSA levels between Benign and premalignant lesions (p value<0.05). Conclusion: PSA is not a specific marker for prostate malignancy, it can be increased in the premalignant and benign condition too like BPH with inflammation.

Keywords: Prostatic adenocarcinoma, Prostate specific antigen, Prostate malignancy, Histology.