European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION, OPTIMIZATION AND EVALUATION OF BIFONAZOLE LOADED PRONIOSOMAL GEL FOR TREATMENT OF FUNGAL INFECTION

Aarthi A., Bhavanishree C., Divyasree S., Gayathri D., Iswarya V.* and Selvi A.

ABSTRACT

The present proniosomal gel investigation was aimed to minimize the adverse effect associated with present topical bifonazole formulation and made to enhance its bioavailability and sustained release by novel proniosomal drug delivery system. Bifonazole is an imidazole and triazole class of antifungal drug which mainly recommended to treat fungal infection. Proniosomes were prepared by coacervation phase separation method using different concentration of non-ionic surfactant (tween, span) and evaluated various parameter like entrapment efficiency, drug content, viscosity, in-vitro drug release, anti-fungal studies and stability studies. The result shows that formulation(F7) containing span 60 showed highest drug content (95.92%), entrapment efficiency(99.14%), in-vitro drug release(84.48%) compared to other formulation. The PH and viscosity of prepared proniosomal gel formulation were found to be 6.8 and 9546cps.

Keywords: Bifonazole, Fungal infection, Proniosomes, coacervation phase separation method, Non-ionic surfactant, In-vitro drug release, Anti-fungal activity.