ANTIMYCOBACTERIAL POTENTIAL OF SILVER NANOPARTICLE AND FORMULATION OF EXTERNAL APPLICATION FOR CUTANEOUS TUBERCULOSIS FROM FICUS HISPIDA
Nikhila V.S.* and Dr. Sapna Shrikumar
ABSTRACT
The green synthesis of silver nanoparticles utilizing various plant extracts has gained considerable attention in recent years due to its simplicity, affordability, and eco-friendliness. The present study investigates the anti-mycobacterial properties of green-synthesized silver nanoparticles (AgNPs) for the treatment of cutaneous tuberculosis. Also referred to as dermal tuberculosis or tuberculosis cutis (extrapulmonary tuberculosis) this condition can manifest in individuals of all ages, regardless of their pulmonary tuberculosis status. The existing treatment for the disease involves the administration of oral anti-tubercular medications, which are associated with numerous side effects, including hepatotoxicity, headache, anxiety, euphoria, insomnia, eosinophilia, and hepatitis. In order to reduce these side effects and improve the effectiveness of the existing therapy, a herbal topical gel has been formulated using the plant Ficus hispida. Furthermore, silver nanoparticles were synthesized from this biofraction, and both the biofraction and the silver nanoparticles demonstrated significant antimycobacterial activity. Overall, the findings suggest that the AgNP loaded antimycobacterial gel could offer a new therapeutic approach with potential anti-mycobacterial activity and can overcome the limitations of existing CTB therapies.
Keywords: Ficus hispida, Cutaneous tuberculosis, Silver nanoparticle, Antimycobacterial activity, Antimycobacterial gel.
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