European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF VANCOMYCIN MICROSPHERES

Naray Navya, M. Vijaya Laxmi* and Vijaya Kuchana

ABSTRACT

The development of oral sustained or controlled release dosage form of Vancomycin has been an interested topic of research for a long period of time. Such drug is difficult to be delivered orally in a sustained or controlled release manner and, Due to its effectiveness and intensive use as a drug of choice in the treatment of colitis, numerous sustained and controlled release formulations of Vancomycin have been made and reported. The microspheres were evaluated with respect to the yield, particle size, incorporation efficiency, in vitro drug release and stability. Microspheres were characterized by FTIR studies. It was found that the particle size and incorporation efficiency of microspheres increases with increasing drug-to-polymer ratio.

Keywords: Vancomycin, Ionic gelation method, Ethyl cellulose, Sodium alginate, FTIR studies, in vitro drug release studies.