DOMPERIDONE-EXCIPIENT COMPATIBILITY STUDIES FOR ADVANCED DRUG DELIVERY SYSTEMS DEVELOPMENT
Mahmoud Mahyoob Alburyhi*, Abdalwali Ahmed Saif and Maged Alwan Noman
ABSTRACT
Domperidone functions by blocking peripheral dopamine receptors, resulting in its gastroprokinetic effects. It enhances gastric peristalsis and promotes coordination between the stomach and duodenum, aiding in the emptying of gastric contents. Additionally, the anti-emetic properties of domperidone stem from its ability to block dopamine (D2) receptors at the chemoreceptor trigger zone (CTZ). The main objective of the present study was to the preformulation studies were performed to know the development of formulation and evaluation of Domperidone Orodispersible Tablets to improve the bioavailability of Domperidone. In the present study that the compatibility was assessed by, FTIR spectroscopy, and melting point apparatus, precompression parameters and powder flow properties. Results showed that physical mixtures of Domperidone and various excipients as mannitol, lactose and avicel PH 102 as diluents, and sodium starch glycolate, croscarmellose sodium, and crospovidone as superdisintegrants and sodium lauryl sulfate as wetting agent were evaluated for preformulation studies parameters. It was concluded that the drug Domperidone was found to be compatible with various excipients which were selected for the formulation development of the Domperidone ODTs. Formulation scientist from his experience and knowledge have to significantly in the preformulation study stage and is an important factor in the ADDS (Advanced Drug Delivery Systems) product development process.
Keywords: Domperidone, Compatibility, Excipients, Development, Preformulation, Formulation, Anti-emetic agents.
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