FORMULATION AND OPTIMIZATION OF ORODISPERSIBLE TABLET OF INDOMETHACIN
Reshu Virmani* and Bansi Dhar Gupta
ABSTRACT
In the present study, Indomethacin is a nonsteroidal anti-inflammatory drug was chosen as model drug for
formulation into pediatric orodispersible tablet. Design of experiment were based on 23 factorial design and total
of eight batches of tablet was formulated. Highly porous tablet with acceptable mechanical strength were
formulated by direct compression technique using a combination of sublimizing agent and superdisintegrant in the
formulation. Camphor and ammonium bicarbonate were chosen as sublimating agents which were subjecting
volatilization at 500C for 8hrs from the tablet matrix. Preliminary trial were carried out to study the effect of
volatilizing agent on disintegration time and hardness of tablet, to study the effect of mode of incorporation of
superdisintegrant, intragranular and/ or extragranular to study combined effect of volatilizing agent and
superdisintegrant to optimize hardness. Wetting time, Water absorption ratio, Porosity drug content and In vitro
drug release in phosphate buffer (pH 6.4 and pH 7.4) were investigated. Surface morphology of prepared
orodispersible tablet was investigated by scanning photograph and SEM. The stability studies were carried out in
accordance to ICH Q1 A guideline for six month to investigate the influence of humidity and temperature on the
crushing strength, disintegration time and drug content.
Keywords: Orodispersible, Factorial Design, in Vitro Release, Stability Studies.
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