European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION OF ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF ARGYREIA NERVOSA AERIAL PARTS EXTRACT

Dr. T. Shivaraj Gouda*, Vaishnavi Shinde and I. Aparna Lakshmi

ABSTRACT

This study investigates the analgesic and anti-inflammatory effects of aqueous and ethanol extracts of Argyreia
Nervosa aerial parts. Given the long-term adverse effects associated with conventional analgesics, NSAIDs and
corticosteroids the search for safer alternatives remains critical. The extracts were prepared through cold
maceration and Soxhlet methods, followed by phytochemical screening and acute oral toxicity assessment to
establish safe dosage levels. Analgesic activity was evaluated using the Eddy's hot plate method, while antiinflammatory
effects were assessed through histamine-induced paw oedema in rats. Results indicated that both
extracts exhibited significant analgesic effects at a dose of 400 mg/kg, as well as marked reductions in paw
volume in the respective models. This study concludes that Argyreia Nervosa aerial parts possess considerable
analgesic and anti-inflammatory properties, suggesting its potential as a safer therapeutic agent in managing pain
inflammation.

Keywords: Argyreia Nervosa, Analgesic, Anti-inflammatory, Eddy’s hot plate, Plethysmograph.