EXPLORING THE POTENTIAL OF ANTIHYPERTENSIVE AGENTS IN DEMENTIA MANAGEMENT: A COMPREHENSIVE REVIEW INCLUDES PHARMACEUTICAL APPROACHES
Sarika R. Jadhav*, Shashikant N. Dhole, Hemant P. Alhat and Nilesh S. Kulkarni
ABSTRACT
Over the time of period prevalence of the hypertension and dementia increases worldwide and they are interdependent. The early age onset of hypertension responsible for different kind of diseases includes coronary heart diseases, cerebrovascular accident and vascular infraction, in some cases leads to white matter lesions, micro bleeds, cognitive deformities and impairment, dys-functioning of the vessels which leads to the vascular dementia. 35 to 84 % patients with hypertension suffering from dementia. The patients who are taking antihypertensive medication significantly reduces the risk of dementia. Randomized clinical trials studies shows that antihypertensive agents like calcium channel blockers, angiotensin-converting enzyme (ACE) inhibitors reduces the risk of dementia by 50%. Novel pharmaceutical approaches help to improve the performance of antihypertensive in the control and management of dementia. This article focuses on potential of antihypertensive agents in control and treatment of dementia also highlighted the pharmaceutical approaches.
Keywords: Hypertension, Dementia, Antihypertensive drugs, Potential.
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