A PARTICLE-BASED FRAMEWORK FOR UNDERSTANDING THE ETIOLOGY OF AUTISM, ALZHEIMER’S, AND DEMENTIA: QUANTIFYING CONTAMINANT PASSAGE IN NEUROTOXICITY
Eric Jesse Kikkert*
ABSTRACT
Neurotoxicity, defined as the disruption of nervous system function by toxic substances, is increasingly implicated in neurological disorders such as autism, Alzheimer’s disease, and dementia. This study presents a novel particle-based framework designed to evaluate how environmental contaminants traverse the blood-brain barrier (BBB) and placenta—critical protective interfaces safeguarding brain and fetal health. By employing a mathematical model rooted in particle physics, we integrate key variables including particle size, charge, and lipophilicity, alongside physiological factors such as blood flow velocity and viscosity, to calculate the probability of barrier penetration. Application of this model to aluminum-based adjuvants reveals a significant likelihood of traversal, highlighting their potential role in neurotoxic risk. These results are corroborated by empirical observations of heavy metals and microplastics in human tissues, emphasizing the necessity of precise, physics-driven methodologies for assessing exposure hazards. This framework offers a robust, evidence-based approach to understanding contaminant transport, providing actionable insights for public health strategies and environmental policy development.
Keywords: Neurotoxicity, blood-brain barrier, placenta, autism, Alzheimer’s, dementia.
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