EVALUATION OF ANTIASTHMATIC ACTIVITY OF ETHANOLIC EXTRACT OF PISTA STRATIOTES LINN (ROOTS)
K. Yuvarani*, D. Ramsundar, G. Dinesh Kumar, S. Mano Ranjith and Dr. P. Deepak
ABSTRACT
The study investigates the effects of Pistia stratiotes extracts on bronchoconstriction induced by spasmogens like histamine, acetylcholine, and serotonin (5-HT), which are implicated in asthma pathogenesis. The extracts were found to inhibit tracheal contractions, with ethanol extract demonstrating the most significant anti-inflammatory activity. The ethanol extract's ability to reduce acetylcholine-induced contractions in guinea pig ileum suggests dual bioactive constituents interacting at muscarinic receptors. This interaction might contribute to enhanced anti-inflammatory effects, making the ethanol extract a promising candidate for asthma treatment. Although the extract showed less potency in inhibiting spasmogens' contractions, it effectively alleviated airway hyper responsiveness and inflammation, potentially by interfering with inflammatory mediators. The study highlights Pistia stratiotes' potential for ameliorating asthma symptoms, although further research is needed to elucidate its exact mechanism of action.
Keywords: Asthma, Phytochemical Screening, Pistia Stratiotes, Ethanolic extract, Pharmaological Screnning.
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