DEVELOPMENT OF NIOSOMAL SUBLINGUAL FILMS FOR ENHANCED PRAZOSIN HCL BIOAVAILABILITY: A HYBRID DRUG DELIVERY SYSTEM
S. Kartheeswaran*, Dr. M. Gopal Rao and Dr. K. Muthusamy
ABSTRACT
In order to improve the bioavailability of Prazosin HCl, a selective alpha-1 adrenergic receptor antagonist with low oral bioavailability because of substantial first-pass metabolism, this study focuses on the development and assessment of niosomal sublingual films. In order to get around this restriction, niosomes were created using the thin-film hydration technique and non-ionic surfactants (Span 60 & cholesterol). Pre-formulation studies verified that the drug was compatible with the chosen excipients, guaranteeing that there would be no major interactions, and they optimized the vesicle size, zeta potential, and encapsulation efficiency. In order to promote quick drug absorption through the sublingual mucosa, these niosomes were subsequently added to sublingual films made using biocompatible polymers. When compared to conventional formulations, the formulated films showed a significantly higher drug release profile, confirming the hybrid drug delivery system's potential to improve bioavailability. The films were characterized for thickness, weight variation, disintegration time, folding endurance, and in-vitro drug release behavior. The findings demonstrate that niosomal sublingual films offer a viable strategy for boosting Prazosin HCl's therapeutic effectiveness by offering a non-invasive, patient-friendly substitute with enhanced bioavailability and a quick beginning of action.
Keywords: Prazosin hydrochloride, Antihypertensive, Span 60, Cholesterol, Niosomal film.
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