A COMPREHENSIVE REVIEW ON ALZHEIMER’S DISEASE: MODERN PHARMACOLOGICAL METHODS
P. Tejeswar, P. Karthik, V. Vennela, Amos Babu* and Dr. B. Thangabalan
ABSTRACT
Introduction: Alzheimer’s disease is a progressive neurodegenerative disorder, primarily affecting older adults and leading to cognitive decline, including memory, reasoning, and language deficits. It is characterized by the accumulation of amyloid-beta plaques and tau tangles in the brain, which disrupt normal cellular function and result in neuronal death. Aim and Objective: The aim of this research is to investigate the molecular mechanisms of Alzheimer’s disease using advanced in vitro and in vivo models, focusing on amyloid-beta and tau pathology, neuroinflammation, and novel therapeutic drug candidates. Methods: Modern in vitro methods such as iPSC-derived neurons, 3D brain organoids, and cortical neuron cultures allow for the study of disease mechanisms and the effects of amyloid-beta and tau. In vivo, transgenic mouse models expressing amyloid plaques and tau tangles are used to monitor disease progression, while advanced imaging techniques like PET and MRI track amyloid accumulation and structural changes in the brain. These approaches, along with optogenetics and cerebrospinal fluid analysis, enable a deeper understanding of the disease’s molecular pathways and the development of targeted therapies. Conclusion: Ultimately, these innovations play a critical role in advancing the diagnosis, treatment, and prevention of Alzheimer’s disease.
Keywords: Alzheimer's Disease, Amyloid-beta, Neurodegeneration and Neurons.
[Full Text Article]
[Download Certificate]
Impact Factor : 8.181 
