European Journal of Biomedical and Pharmaceutical Sciences

SUSTAINED RELEASE PELLETS OF BOSENTAN FORMULATION AND BIOPHARMACEUTICAL EVALUATION

Tanu Patel*, Dr. Vivek Gupta, Nida Musheer and Gyan Singh

ABSTRACT

Designing novel controlled and delayed release oral formulations is made possible by multiparticulate drug delivery technologies. In pharmaceutical applications, multiparticulate dosage forms are becoming more and more popular than single-unit dosage forms. In the current study, bosentan pellets were made for the ongoing medication administration for a long time. The oral bioavailability of the antihypertensive medication bosentan is 50%. Sugar pellets containing EC as sustained release polymers were used to create bosentan sustained release pellets, and the fluidized bed coating process was used to coat the pellets. For every formulation, physicochemical characterizations such as SEM, DSC, and in vitro dissolution experiments were carried out. Among the several formulation batches, it was discovered that BEC-4 and BEC-5 released the medication for a longer duration—up to 18 hours. The drug release from the polymer increased as its concentration rose. The number of pellet formulations was decreased. The profile of persistent drug release has

Keywords: Bosentan, pellets, Sustained release, ethyl cellulose, formulations, Coating.