DESIGN, DEVELOPMENT AND CHARACTERIZATION OF NANOSTRUCTURED LIPID CARRIERS LOADED WITH PROGUANIL.
Indrayani S. Pagare*, Utkarsh R. Mandage, Ashwini I. Patil and Jagruti R. Patil
ABSTRACT
Nanotechnology and nano-science hold significant promise for advancing various research fields and applications, attracting substantial investments globally. However, their implementation raises safety, regulatory, and ethical challenges. Nano-materials' unique properties, such as increased surface area and quantum effects, enhance reactivity, strength, electrical characteristics, and in vivo behavior. Nanoparticles, defined as particles sized 10-1000 nm, play a crucial role in drug delivery systems by improving oral uptake efficiency, patient compliance, and market expansion for injectable drugs. Colloidal drug carriers, including liposomes, micelles, and polymeric nanoparticles, enhance drug specificity, bioavailability, and protection against enzymatic degradation. These carriers also facilitate drug passage across the blood-brain barrier. Ideal carrier systems should be non-toxic, possess high drug-loading capacity, provide controlled release, and be economically scalable. Nanometric colloidal carriers include lipidic flexible particles, nanoemulsions, nanosuspensions, polymeric nanoparticles, solid lipid nanoparticles, and nanostructured lipid carriers, each offering unique advantages in drug delivery.
Keywords: Nanoemulsion, Nanosuspension, Lipid carrier.
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