European Journal of Biomedical and Pharmaceutical Sciences

NANOSPONGES: RECENT TECHNIQUE FOR ENHANCEMENT OF SOLUBILITY

Umesh Panchal*, Sakshi Gade, Vishakha Ranshur and G. R. Godge

ABSTRACT

In recent years, nanosponges (NS) have gained tremendous impetus in drug delivery through nanotechnology. Nanosponges are capable of providing solutions for several formulation related problems. Nanosponges are tiny sponges with a size of about a virus, which can be filled with a wide variety of drugs. These tiny sponges can circulate around the body until they encounter the specific target site and stick on the surface and begin to release the drug in a controlled and predictable manner. Because the drug can be released at the specific target site instead of circulating throughout the body it will be more effective for a particular given dosage. Another important character of these sponges is their aqueous solubility; this allows the use of these systems effectively for drugs with poor solubility. Owing to their small size and porous nature they can bind poorly-soluble drugs within their matrix and improve their bioavailability. They can be crafted for targeting drugs to specific sites, prevent drug and protein degradation and prolong drug release in a controlled manner.

Keywords: Nanosponges, Cyclodextrins, Bioavailability.