European Journal of Biomedical and Pharmaceutical Sciences

FORMULATION AND EVALUATION OF QUINAPRIL HYDROGEL TABLETS

Eswar Kumar A.*, Dr. R. Suthakaran, Adithya and Sharada Nalla

ABSTRACT

In the present study Quinapril hydrogel tablets using carbopol, MCC, Na.CMC were prepared for the controlled release of Quinapril. The hydrogel tablets were prepared by Direct compression technique. Total 9 formulations were prepared by varying drug-polymer ratio and concentration of polymers and cross linking agents in order to study the swelling and in vitro drug release profiles. The compatibility of drug with the polymers was confirmed by Fourier transform infrared spectroscopy (FT- IR) the nature of the drug in the hydrogels formulations. It was found that as the concentration of cross linking agents were increased, there was a decrease in swelling. The release data showed that, as the concentration of Polymer was increased; swelling decreased in the acidic pH but increased in the basic pH resulting in increased release of the drug in the intestine.

Keywords: Quinapril, Na. CMC, MCC, Carbopol, Mg. Stearate.