SYNTHESIS CHARACTERIZATION AND MOLECULAR DOCKING STUDY OF SELECTED COMPOUNDS ON ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES Rohit Kr
Rohit Kr Vishwakarma*, Jitendra Malik and Gyan Singh
ABSTRACT
Objective:
The development, characterization and molecular docking of novel antibacte rial agents. Schiff bases
are reported to possess a broad range of pharmacological activities, which also include antibacterial, antifungal
activity etc. With this background, novel Schiff bases were synthesized. Method: To synthesize characterization
the of Schiff base legend and Metal complex complex, molecular docking study help to improve the already available drugs
potential and also helps to synthesise novel drugs for the suitable biomolecular target area. The synthesised metal
complexes were used to dock wit h the DNA hexamer unit and amino acid units. Result and Conclusion: The
present study provides information in respect of The metal complexes were synthesized using the backbone of
Schiff base ligands and characterized using spectral techniques like UV Vis, FT IR. One of the ligand was isolated
in crystal forms which give the exact structure of the particular compound and additionally supports the formation
of metal complexes using the moiety. The spectrum of the copper complexes explains the paramagnetic na ture.
The structures are confirmed by various spectral methods. The molecular docking study supports the binding
nature of the synthesized complexes with biomolecule. The antifungal and antibacterial result of the metal
complexes explains such compounds ac ts like potential anti infection drugs.
Keywords: molecular docking, biomolecular, antibacterial, Schiff base, ligand.
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