European Journal of Biomedical and Pharmaceutical Sciences

TO FORMULATE AND EVALUATE ORAL STRIPS FOR QUICK RELIEF FROM ORAL ULCER

Srushti R. Chaukone*, Nikita S. Alone, Nishant D. Shedmake, Prof. Manisha R. Chavhan, G. J. Rathod and Dr. Manisha D. Kitukale

ABSTRACT

Fast dissolving strips (FDS) have emerged as a novel oral drug delivery system offering rapid disintegration upon contact with the buccal mucosa, typically within seconds, without the need for water. This improves patient compliance, particularly among pediatric, geriatric, and dysphagic populations. By facilitating direct absorption into systemic circulation, FDS bypass first-pass metabolism and gastrointestinal degradation. Given the limitations of conventional tablets and capsules, which pose swallowing difficulties for 26–50% of patients, FDS present a patient-friendly alternative. Which contain API (lidocaine 4.5gm & Choline Salicylate 1.5gm), Polymer (HPMC 5gm), Plasticizer (Glycerin 4.5gm), Saliva stimulating agent (Citric Acid 0.5gm), Sweetening agent (Saccharine 0.5gm), Surfactant (Sodium Lauryl Sulphate 0.06gm), Propylene glycol(1), Peppermint oil(0.4gm), and water (QS) Recent developments have focused on formulation techniques, evaluation parameters, and industrial adoption of transdermal technologies to produce thin oral films.

Keywords: Fast dissolving strips, Oral mucosa, Solvent casting, Disintegration, Permeability, Patient compliance.