LEVELS OF FIBRINOGEN AND SOME HAEMATOLOGICAL PARAMETERS IN PATIENTS WITH UNCOMPLICATED MALARIA IN NNEWI, NIGERIA
Ehiaghe F. A., Onuoha R. and *Ehiaghe J. I.
ABSTRACT
Malaria infection continues to be serious global public health issue especially in Nigeria. This cross-sectional study was conducted to determine the levels of fibrinogen and some hematological parameters (mean corpuscular volume (MCV); mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC)) in patients with uncomplicated malaria in Nnamdi Azikiwe University Teaching Hospital (NAUTH) Nnewi, Anambra State, Nigeria. One hundred and twenty-eight participants comprised of sixty-four (64) patients diagnosed with uncomplicated malaria and sixty-four (64) apparently healthy participant without malaria parasitemia (control group) were recruited for the study using simple random sampling method. Participants (test and control groups) were aged between 18 and 45 years and were age matched. Blood samples were collected from each participant for the determination of MCH, MCHC, MCV and fibrinogen levels. Malaria parasite determination was done using Giemsa stained thick and thin blood film for microscopic detection of malaria parasites. MCH, MCHC and MCV levels were determined using a three part Biobase hematology analyzer (BK-6190, China) while fibrinogen level was determined using Clauss method. Results showed significantly increased mean plasma fibrinogen level (242.200±36.351 Vs 217.800±22.183; p = 0.003) and decreased MCH (29.716±0.000 Vs 31.300±0.000; p = 0.033) and MCHC (329.033±15.985 Vs 356.000±27.030; p = 0.001) with no significant difference in MCV (p = 1.000) levels in the patients with uncomplicated malaria compared to the control group respectively. There was a significant negative correlation between Fibrinogen level and MCH (r-value = - 0.375; p-value = 0.041). Uncomplicated malaria significantly increased the level of fibrinogen. Thus, suggesting that increase in fibrinogen could be protective in cases of uncomplicated malaria.
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