DEVELOPMENT AND EVALUATION OF OMEPRAZOLE BUCCAL FILM
Dr. B. Premkumar*, M. Saranya, M. Shibani, P. Manju Deepa, S. Marylin Jeya Praya, S. Punithavel, A. Logesh, T. Gayathiri and Sheba Sebastian
ABSTRACT
Buccal tablets were prepared using mucoadhesive polymers like Chitosan, HPMC K4M, Na CMC & amp; Sod. alginate by direct compression technique. Buccal tablets were characterized for number of parameters like Hardness, weight uniformity, thickness, % friability, swelling index, mucoadhesive strength, surface pH, drug–excipient interaction study, drug content uniformity and In vitro drug release study. The continuous secretion of saliva and its subsequent swallowing can lead to substantial drug depletion from the dosage form and hence low bioavailability. Therefore, other transmucosal routes such as nasal, rectal, vaginal, ocular and oral mucosae are being considered as alternatives to conventional oral dosage forms for drug delivery to avoid the above disadvantages associated with conventional oral delivery (i.e., tablets, capsules, syrups, etc.). Of these routes of delivery, the buccal oral mucosa has emerged as one of the target sites for administration of drugs in a wide variety of dosage forms, particularly for those drugs targeted for local delivery in the oral cavity and systemic absorption.
Keywords: Buccal Tablets, Polymers, Mucoadhesion / bioadhesion.
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