European Journal of Biomedical and Pharmaceutical Sciences

EVALUATION AND DRUG STABILITY STUDIES OF DIFFERENT BRANDS OF CLOPIDOGREL TABLETS AVAILABLE IN SANA’A CITY MARKET, YEMEN

Maged Alwan Noman, Mahmoud Mahyoob Alburyhi*, Tawfeek A. A. Yahya and Abdalwali Ahmed Saif

ABSTRACT

Clopidogrel is a medication orally administered drug used as to reduce the risk of heart disease. The most of the
companies seek to achieve high quality of drug, but often it is very difficult to achieve. The aim of this study is to
investigate quality parameters of some marketed Clopidogrel tablets at Sana'a City Market, Yemen. Six different
marketed brands of Clopidogrel 75mg tablets available in Sana'a City Yemen, were collected from different
pharmacies. Quality parameters, like weight variation, hardness, thickness and loss on drying test were determined
according to established protocols. with the in-vitro dissolution test, potency, disintegration time were also carried
out. The percentage of dissolution and assay were carried out used UV-spectrophotometer. All the brands comply
the Pharmacopoeia requirements as they offer acceptable weight variation range, the hardness of all tested brands
was within range and no significant differences in disintegration times as they disintegrated within 10minutes. In
case of dissolution rate, all brands showed acceptable dissolution time as they released more than 80% of drug
within 45 minutes. The most of selected brands also meet the assay specifications. This study suggested that the
most of commercially tested brands of Clopidogrel tablets marketed in Sana'a City, Yemen comply with the
pharmacopeia specifications and quality control specification, as the following: Plavix > Cloval > Plaviscot >
Plavilate > Plavicare > Plavised.

Keywords: Clopidogrel, Drug Stability, Evaluation, Sana'a City Market, Yemen.