BIOCHEMICAL PROFILE AND STUDY OF ANTICONVULSANT ACTIVITY OF ETHANOLIC EXTRACT OF PEURARIA TUBEROSA
Radhika Gopichandani* and Sandeep Jain
ABSTRACT
The present investigation was carried out with an objective to evaluate and establish the anti-epileptic action of ethanolic extract of Peuraria tuberosa leaf. The ethanolic extraction was carried out using soxhlet apparatus and the yield of extract was obtained to be 17.08 %. The findings of the phytochemical analysis suggest the presence of alkaloids, saponin, anthraquinone, phenolics, terpenoids, sterols, and flavonoids in the ethanolic extract leaves. The total flavonoid content of the extract of Peuraria tuberosa leaf was calculated to be 8.19 mg/100 mg quercetin equivalent. The total phenolic content of the extract of Peuraria tuberosa leaf was calculated to be 61.63 mg/100 mg gallic acid equivalent. The total tannin content of the extract of Peuraria tuberosa leaf was calculated to be 16.61 mg/100 mg catechin equivalent. The total saponin content in the extract was gravimetrically determined and was found to be 1.18 g per 100 g of extract. The anticonvulsant action was determined using pilocarpine induced convulsions model. The results indicated that the extract of Peuraria tuberosa leaf was able to decrease the onset of hind limb extension significantly and also it abolished the occurrence of clonus in the test animals.
Keywords: Peuraria tuberosa, anticonvulsant, pilocarpine-induced, saponin, tannin.
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