EVALUATION OFANTIDIABETIC ACTIVITY USING GENTIANA OLIVIERI GRISEB AND FICUS RACEMOSA LINN ON ALLOXAN INDUCED ANIMAL MODEL
Dr. Anupama Koneru, Dr. J. Raghuram* and Neha Sultana
ABSTRACT
High blood glucose levels are a hallmark of diabetes mellitus, a metabolic illness that has plagued humanity for millennia. It's possible that insulin insufficiency or insulin resistance is at blame. Diabetes mellitus (DM) is a chronic metabolic illness caused by a complex interplay of genetic predisposition, environmental exposure, dietary choices, physical activity level, and psychological stress. More evidence to support the claims stated and insights on how to most effectively treat diabetes might result from this. By enhancing glucose tolerance and decreasing blood glucose levels in alloxan-induced diabetic rats, both single-dose and repeated-dose tests reveal that the extract has significant anti- hyperglycemic efficacy. The glucose tolerance test results showed that both the extracts and the market standards significantly reduced blood glucose levels. Hypoglycemic effects similar to those of commercially available drugs indicated that the active fractions could be responsible for regenerating cells in alloxan-induced diabetes. The findings provide evidence for a probable mechanism of the anti-diabetic effect of extracts of selected medicinal plants, namely, the promotion of pancreatic repair.
Keywords: blood sugar, Hyperglycemia and body weight.
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