European Journal of Biomedical and Pharmaceutical Sciences

STUDY OF PLANT SECONDARY METABOLITES AND HYPOLIPIDEMIC ACTIVITY ALBIZIA ODORATISSIMA LEAVES EXTRACT

M. D. Noor Ali, Vinod Dhote* and Kanika Dhote and Surendra Jain

ABSTRACT

The present study investigates the phytochemical constituents and hypolipidemic activity of the aqueous leaf extract of Albizia odoratissima, a traditionally used medicinal plant. The extract was subjected to preliminary phytochemical screening, which confirmed the presence of several secondary metabolites including flavonoids, phenols, saponins, diterpenes, and sterols. Quantitative estimations revealed significant levels of total phenolic (0.356 mg/100 mg) and flavonoid (0.572 mg/100 mg) content. The hypolipidemic potential of the extract was evaluated in a high-fat diet (HFD)-induced hyperlipidemic rat model. Administration of Albizia odoratissima extract at doses of 100 and 200 mg/kg for 28 days significantly reduced body weight gain and serum lipid parameters, including total cholesterol and triglycerides, while increasing high-density lipoprotein (HDL) levels. These effects were comparable to the standard hypolipidemic drug, atorvastatin. The findings suggest that the hypolipidemic activity of Albizia odoratissima may be attributed to its rich content of bioactive phytoconstituents, supporting its traditional use in the management of lipid disorders and offering potential as a natural therapeutic agent for hyperlipidemia.

Keywords: Albizia odoratissima, Secondary Metabolites, Flavonoids, Phenols, Hypolipidemic Activity, High-Fat Diet, Lipid Profile, Natural Antihyperlipidemic Agent, Herbal Medicine, Aqueous Extract.