European Journal of Biomedical and Pharmaceutical Sciences

ANTI-INFLAMMATORY ACTIVITY OF PULICARIA DYSENTERICA LEAF ON CARRAGEENAN INDUCED PAW EDEMA IN ALBINO RAT

Ramanand Patel*, Abhisek Kumar Yadav, Bhavana Yadav, Dipendra Yadav, Manoj Kumar, Bal Karan Prajapati

ABSTRACT

This study investigated the anti-inflammatory potential of the methanolic extract of Pulicaria dysenterica. (Asteraceae) in Wistar albino rats after topical application (250, and 500mg/kg) in the form of gel. This was done using the carrageenan-induced paw edema method (acute inflammatory model). The methanolic extract showed significant suppressed granuloma formation. Collectively, these data demonstrate promising anti-inflammatory activity against both acute and chronic inflammation. It was discovered that none of the dosages of the extract of Pulicaria dysenterica used for acute oral toxicity was non poisonous. Even at the doses used, Pulicaria dysenterica extract did not cause any mortalities. Carrageenan subplantar injection in rats resulted in a time-dependent increase in paw thickness. At 0, 3, 5, and 24 hr after the injection of carrageenan, the thickness was measured. In the groups who received a vehicle injection, this rise started to be noticeable at 1 hours and peaked at 3 hours. However, treatment with 250 mg/kg and 500 mg/kg of extract and a prescribed dose of Diclofenac (10mg/kg) decreased the inflammation caused by carrageenan considerably (p≤0.05) after 24 hour in all phases of the trial.

Keywords: Anti-inflammatory activity, Pulicaria dysenterica, Diclofenac, methanolic extract, Carrageenan model.