European Journal of Biomedical and Pharmaceutical Sciences

ANTI-INFLAMMATORY ACTIVITY OF HYDRO ALCOHOLIC LEAVES EXTRACT OF H. INTEGRIFOLIA ON CARRAGEENAN INDUCED PAW EDEMA IN ALBINO RAT

Sushil Kumar*, Dr. Bhavana Yadav and Manoj Kumar

ABSTRACT

To determine the anti-inflammatory activity of hydro alcoholic leaves extract of Holoptelea Integrifolia on Carrageenan-induced inflammation in Wister albino rats and compare to Standard drug (Indomethacin) This study investigated the anti-inflammatory potential of the of Holoptelea Integrifolia. (Ulmaceae) in Wistar albino rats after oral administration (250, and 500mg/kg). This was done using the carrageenan-induced paw 0.1% in 1ml edema method (acute inflammatory model). The hydro alcoholic extract showed significant suppressed granuloma formation. Collectively, these data demonstrate promising anti-inflammatory activity against acute. It was discovered that none of the dosages of the hydro alcoholic leaves extract of Holoptelea Integrifolia used for acute oral toxicity was non toxic. Even at the doses used, H. Integrifolia extract did not cause any mortalities. Carrageenan sub plantar injection in rats resulted in a time-dependent increase in paw thickness. At 0, 3, 5, hr after the injection of carrageenan, the thickness was measured. In the groups who received a vehicle injection, this rise started to be noticeable at 1 hours and peaked at 3 hours. However, treatment with 250 mg/kg and 500 mg/kg of extract and a prescribed dose of indomethacin (10mg/kg) decreased the inflammation caused by carrageenan considerably (p≤0.05) after 24 hour in all phases of the trial.

Keywords: Anti-inflammatory activity, Pulicaria dysenterica, Diclofenac, methanolic extract, Carrageenan model.