ANTIDIABETIC ACTIVITY OF POLYHERBAL PLANT EXTRACT ON ALLOXAN INDUCED DIABETS IN WISTAR ALBINO RATS
Anil Kumar Sonkar*, Dr. Bhavana Yadav and Manoj Kumar
ABSTRACT
Diabetes mellitus is a chronic metabolic disorder marked by elevated blood glucose levels due to impaired insulin secretion or action. The present study investigates the antidiabetic activity of a polyherbal plant extract comprising Trigonella foenum-graecum (seeds), Momordica charantia (seeds), and Mangifera indica (leaves) in alloxan-induced diabetic Wistar albino rats. Diabetes was induced by a single intraperitoneal injection of alloxan monohydrate (150 mg/kg body weight). Diabetic rats were randomly divided into five groups: normal control, diabetic control, standard (glibenclamide-treated), and two groups treated with the polyherbal extract at doses of 250 mg/kg and 500 mg/kg body weight, respectively, for 21 days. The polyherbal plant extract significantly (p < 0.05) reduced fasting blood glucose levels in diabetic rats compared to the diabetic control group. Additionally, treated animals exhibited improvements in body weight, lipid profile (decreased total cholesterol, triglycerides, and LDL; increased HDL), and antioxidant enzyme levels (such as SOD and catalase).These findings highlight the potential of this polyherbal plant extract as a complementary therapeutic approach for diabetes management.
Keywords: Antidiabetic activity, polyherbal extract, Trigonella foenum-graecum, Momordica charantia, Mangifera indica, alloxan-induced diabetes, Wistar rats, phytotherapy.
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